Texas Hold'em and Omaha are the two most popular types of modern poker. The seniority of the combinations is also the same, Royal Flush is the highest combination in both Omaha and Hold'em. The seniority of the combinations is also the same, Royal Flush is the highest combination in Omaha and Hold'em. Second difference is that in Omaha we must use two pocket cards. In both Omaha and Hold'em, any hand is a combination of 5 cards. That is, a combination of pocket and community cards. But in Hold'em and Omaha, hole cards are used to build a 5-card hand in different ways.