Wait it out, then pounce..
When at table with chip leader, hell bent to eliminate everybody, it's best , to be patient; wait the chip leader out, don't play his unfair game.
When you get a solid pocket pair, suited, etc., make your move.
If the guy is bullying, uncalled, eliminating others, turn it around, make the call, surprise the leader, maybe you can eliminate the bully chip leader We have all seen this scenario.
Even if you don't make any money, at least you got entertainment value of making the chip leader work hard for the chips.