Instincts
Well, I think that in poker everything is related, and not only related to the strength of your holding.Whenever I am quite sure about my understanding of what is happening on the table, and that I find the good spot to steal by 3 betting, or set up a steal on the flop by continuation betting after 4 betting pre, I would go for it no questions asked even without looking at my hand.
But still, this is not something you do without going through a quite complex process of understanding your opponents state of mind, and the rules of position and the stack sizes and many other factors that may occur while making the decision to make that kind of move.
Then of course, your instincts would lead you to those spots where you'd make a lot of money.