The main difference I've noticed in the play in Rush (5NL) is that players will fold marginal hands much more often, so it is very susceptible to blind-stealing when raising from Button, CO or even CO-1. My formula is to try to steal as often as I have decent raising hand and occasionally with nothing. If I get reraised I'll usually just fold. But I haven't seen any form of poker where raising from the button so consistently gets folds.
On the reverse you are going to have to face steal attempts more often when you are in the blinds. I will to reraise or call with a strong hand in the bb and sometime 3bet light with marginal hands. I also do that in the small blind, but less often and in both cases usually only when there is one other player or if I have a monster.
A downside of the tendency of people folding is that when you want someone to play back at you often everyone just disappears and you are left there holding your AA or KK that you've waited 200-300 hands to get. In a normal cash game someone might have, simply out of boredom or frustration, looked you up while holding K-10 or something and you'd have won something other than the blinds.
But generally Rush is kind of distilled, essential poker. One thing it is good for, because so many hands come in so fast, is for you to learn vividly how so few hands are really playable, how so many good hands are wasted because of bad position or the betting of others, how many good hands get beat and how many great hands get flat busted. So you have to imagine how if you were playing a normal cash game you would need the patience of Job to play with the folding discipline that is much easier in Rush.
You learn you have to overcome all the above, not to mention the negative emotions that accompany them, and play well for your legitimate wins, to show any profit. Not easy, which is why so few can do it.