Well, setmining needs couple of conditions to be profitable. Under setmining I mean => you get set, you almost never fold. Not unless its tight opponent and super-duper wet board.
For profitable setmining:
- deep enough effective stacks (30-100 BB)
- too deep stacks cannot be just used for setmining (over 100BBs). You need to be able to play postflop with or without a set.
- opponents which will let you steal blinds at least sometimes
- opponents which will call from time to time (not opponents which will fold or 3bet).
- AND opponents willing to build big pot with some TPTK or two pairs.
And that last condition is becoming tricky on NL25 and higher stakes. At these days the opponents there will not give you so much part of stack with weak
hands like TPTK. Not unless you are known as super agro maniac.
I expect from the question you have more tight image. You will hit set to higher set at very rare occasions, but its ONLY in those occasions where clever opponent is willing to go all-in.
So my answer: you can keep setmining with low pairs, but what you need is extend your moves with the rest of cards. So your setmining is more hidden, and your bet on flop/turn with set are more balanced between monsters and bluffs.