Different stages in a Tournament require a Different approach, as you have already stated players tend to tighten up their play coming up to the money bubble, So yes it can be an advantage to play more aggressively especially with better hands and push players off the Blinds.
There is nothing worse than getting A/A dealt and having them cracked by a garbage hand that would normally be folded pre-flop, and your opponent spikes a three of a kind with 7/2 off, So it's time to go big or go home!
Target the smaller stacks, because they are usually the tightest of players, all trying to survive long enough to make the money, but avoid the bigger stacks that might try and target you, Let's be honest "Big Fish eat Smaller Fish, but there are some Sharks out there"