This is a discussion on Running it many times within the online poker forums, in the Online Poker section; I have found that runing it several times is a hot topic that many people have dissagrements about. what is the best amount of times
If you are using aggressive bankroll management, or if you are prone to go on tilt after losing, then running it twice, or if possible even more, will be beneficial for you, because it reduce the risk of big losing sessions. If however you have plenty of bankroll and no tilt problems, but maybe your opponents have, then running it once is better, because it might put your opponents on tilt, if they lose.
I have found that runing it several times is a hot topic that many people have dissagrements about. what is the best amount of times to run it?
There really isn't a correct answer to this question. The more times you run it the less variance you will experience in your overall session results. If you are always ahead when the topic comes up to run it 2x or 3x then I'd say just run it once (just like Phil Galfond) because you will tend to put you opponents more on tilt and they will be less inclined to call future bets that put them all in knowing that you won't run it more than once.