Playing against multiple players?

P

par

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I am learning about putting your opponent(s) on a hand range and combos, I am studying about combos and from what I understand is that, when you are in a hand, against one opponent and let's say the flop comes Qh9c4d and I think my opponent has a set or a open ended straight draw, we need to count the combos for each individual hand, the OESD would have 16 combos with JT and 18 combos for the sets. We are using the card removal here, our opponent cannot have the cards on the community board, so we remove some combos, we have QsTc, so we again remove some combos because those cards are also not available to our opponent. Am I right here?

The second question I have is:

Say we are against two opponents instead of one, how does this change? I would need to put both of my opponents on a range of hands, would I need to eliminate, even more combos because my second opponents cards also come into equation here?
 
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