Like everything else in poker, it really is situational, dependent upon reads on opponents, your image at the table, your playing style, your ranges, their ranges, table texture, board texture, etc.
It's really difficult to give a specific response that would work for you to such a general question, but it sounds like would benefit by tightening up your range a bit in EP and letting go of hands that are easily dominated, such as KQ, KJ, etc.
The place for those kinds of hands, especially in an unopened pot, is in later position.
I do disagree that "you will lose most of your chips in early position". If that happens to be your case, then you are playing too many hands from there. Early position is a great opportunity, for example, to set mine, if the implied odds
and other variables are present.
If you want to be more specific or even post some hands, then we could probably help you a bit more in this regard.
Thanks for your post