I've never had trouble with 6-max. Up until last month it was pretty much all I played.
Here's my thought's on 6-max, and I'd like to get Bw07507's opinion on them.
I think you can show a profit in the 6-max tables by pretty much playing it like a FR, though a bit looser. But overvaluing position is a big mistake people make, so watch out.
The difference between FR and 6-max isn't massive, but (like at the end of a tournament) drawing hands like middle/small suited connectors are less
valuable in while big pocket-pairs and A/face hands are more valuable.
Set mining is probably a little less valuable than in FR, but it's still worth doing. (Basically, the odds
of someone having a hand that'll pay off your drawing hand are less)
Don't get into the trap of overvaluing position and be willing to fold several rounds if you need to.
Choosing your table is a bigger factor in 6-max as well. Stats are averaged out over a smaller group of players, so the wild players have a greater impact on the stats.
Anyway, that's just my two cents. I might be saying and doing another, but I think that's how I end up playing, which has been profitable so far.