You will have zero fold
equity.
You will be a target of aggressive players.
You're out of position. In position you might be able to check behind and hit your set on the turn. Out of position checking, you might end up a target.
If you are shallow stacked, if anyone raises "the limper" you won't have implied
odds to call.
If you are deep-stacked, you will have lead or trap to build a pot which might scare out opponents.
Again out of position is awkward if you hit your set, but a possible flush or straight draw is on the board.
I am kind of a beginner, so take that with a grain of salt.