Typically its a mistake to call a 3-bet with a small pair, and one of the reasons is, you have a higher risk of getting into a set over set situation, than you do in a single raised pot, because the 3-bettors range contain a high density of big pairs like TT-AA. Another way to avoid set over set situation and increase your winrate is to simply ditch the smallest pairs from early position, and also in a lot of situations, when someone else have entered the pot. If you take on every single setmining spot, you are almost certainly losing a lot of money overall especially with the absolute worst pairs like 22-44.
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