Play in position (IP) whenever possible.
Think thrice before getting in a hand if you will find yourself out of position (OOP).
So your opening and playing hand ranges should be tighter when OOP.
Chasing draws,
bluffing / semi-bluffing, 3-bet success, etc all is better when done IP.
Position is like Oxygen in poker, don't get out of it.
You can counter some of the positional disadvantage via getting initiative (raising/reraising your opponent(s)).
Obviously position doesn't matter anymore once you are all-in.