I use the feeling usually to play the bottom of my range. If I have a reason to play a certain hand, I will, I'll explain:
I'm at the CO with A5o, the BTN is at 80% ATS and plays 15%of his range. The SB is at 10% ATS and wide with 45% range. The BB seems like a good player with something like 30% range and 28%3b. In this position I want to try to steal the blind, as the BTN won't defend it, the SB can call wide, but he has no position, the BB can 3bet, that's the only issue, but we would have position. So I'd raise for 3,5BB to try and steal. If they call I'm ok with it, as I will put a lot of pressure.
An other exemple:
I'm the CO with A5o, the BTN is 28% range and 80% ATS, he has 32%3bet, and is a very agressive and good player overall. Personnally I won't bother, and won't even look for what's going on in the SB and BB, and fold waiting a better hand, or play the BTN when he is in the SB.