Finding the Sickest Spot

Hello.

So, I've been applying the mentality of "finding the sickest spot" to my overall strategy, and it seems to be working.

The question is when you see the spots, but don't have the cards, is it profitable bluffing then?

I find I bluff probably less often then I should, but with the "finding the sickest spot" mentality, I find myself folding preflop more.

It is easier to bluff a dry board and one opponent
Sick spot would be bluffing on a wet board multiple opponents kamikaze lol.

Figure out your opponents hand range and then try to bluff them based on if the board is likely to hit their range.

for me it always depends on how many players are involved and what I see of each player