Especially if the Villain is also in early or mid position, I would often just call a 3-bet with QQ when 150BB deep. I feel, that if we 4-bet, we start to narrow the opponents range in a rather unfavourable way for our hand. One might then say, it this mean, we are 4-betting only aces or kings, and if this is not unbalanced. And it kind of is. But especially if its UTG open and UTG+1 3-bet, this action is already so strong, that a perfectly acceptable GTO strategy would be to just call with our entire range including AA or KK. In that way the opponent cant just
bluff us to high heaven postflop, and we can possibly get away from hands like QQ and JJ on low boards, because we have AA, KK and sets to call him down with.