Depends on who you are playing with/how many players in the pot(aggressive,tight player(s)), how the hand played out before the flop(was there a lot of raising going on or was it a limped pot) and the board texture(is it a dry board or a wet board?)
Ex. If there is a lot of people in the hand 5+ players on a dry board in a limped pot you shouldn't go broke with two pair that often especially if there is a lot action on the flop,turn,river. Thats not to say you shouldn't be aggressive with your hand and get value from it, but you should definitely be cautious if you get played back at.