If you're talking strictly Broadway cards and the ones I'd least like to play, it'd be J10o. Granted, I rarely play it to begin with, but at least they're easier to fold if I end up disliking the flop and get bet into. As for what I somewhat dislike to play most, it'd be Pocket Aces. Of course it's the best hand pre-flop, but I personally have the worst luck with it when playing online and they're tough to fold against a hard-to-spot set or someone making a 5-card hand on the river and already having a lot of pot equity.
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