I like to loosen up against the tight asses. Somebody who keeping it predictable with 4-5x BB raise with big cards, and a Blind steal every so often, I like calling with, suited connectors, maybe just a couple rags.
When your rags hit a pair or straight, a lot of these rocks will do their continuation bet, that's when you just start letting out the rope to hang themselves with.
Of course if the flop comes up with big cards, run for the hills, and try again next time.
I also stay away from playing the marginal hands as any mid mid-hi pair you hit will likely be out kicked, or you could come out with the lower end of a straight.