If you have a relevant sample of hands on both limits, you will see that microstakes are much easier to play.
A thought experiment, keep in mind this is simplified a lot:
I allways liked the following example a lot: you're siting in a casino at 3 clock in the morning and notice a new player sitting down. Player has a stack of 100bb is first to act and shoves his entire stack. It folds to you in the bb and you are looking down on Q9s. Hold or fold? Now we have 2 potential players. A the drunk multimillionaire B the regular. Who is easier to play against? In this case we know quite certain that the regular will never do this without atleast the 15% range of the best cards he has. Therefore we have an fold. Now vs the drunk millionaire we most likely have a call, since for all we know he could be doing this with any 2 cards. So you see, that even though we are facing a worse player, we have a hard time putting him on a range of hands, BUT this doesn't make our decisions harder. For instance a regular will be jamming a polarized range here quite likely. Thus half of his range is garbage and the other half will crush us. Therefore we will have a ez time thinking trough a hand like a regular does, but putting a drunk maniac on a range, gl with that. Now who do you think will make us more money? The drunk guy or the regular?
Also keep rake in mind. A lot of players would be profitable if the rake wasn't as high. This doesn't apply to Nl2 on Stars though, the have pretty low rake there.