This is a discussion on Short Handed vs Full Ring Profitability? within the online poker forums, in the Cash Games section; Short handed play involves more variance but perhaps also more room for exploitation.
I suppose full ring has potential for bigger pots.
What do you
If a large number of people play tight at a full table, you won't see big pots too often. This is a good place for patient players. But when a lot of players are involved in the hand, then there is still a chance for big pots.
On the contrary, the game is more aggressive at 6-max tables. Consequently, fewer folds will be performed.