Flopped the high straight when 6, 7 ,8 hit the board and I had 9 10. The issue is two of the flopped cards were hearts. I bet pot, villain called and turn came up still a winner for me. Bet pot again, villain calls, and a heart hits on the river which ends up as a loss for me. How would you play a hand like this knowing your opponent may call to the bitter end hoping to catch?

in PLO ,when you have the moment nuts I think you always had to rise pot

the need to increase the pot is fully visible, so the opponents fold increases and you eliminate hands that can beat yours on the turn or the river.