You cannot raise him just because you think he doesn't have it.
If you want to bluff raise him, you want to force a fold so you need to represent a hand.
Lets say you are in the BB, BTN raises 2.5x, you call and flop comes A7Qr.
He bets and you raise. Does that look right? There aren't any big aces you wouldn't 3bet preflop and a 7 as well as a Q doesn't justify a raise here. However AK, AQ and AJ are in his range while you just said "I don't have premium aces" because you called.
So no matter what he has, he can just shove it and you cannot call.
If you think he doesn't have it, you need to float OR you need a hand with backup
equity. Lets take the hand above and change it from rainbow to double suited and you have a OESD + a flush draw with KTs.
Now you could raise him because if he doesn't fold, you have a couple of outs to make a real hand.