In position against a raise with AQs, I will generally smooth call as it plays so well after the flop, I don't want to be 4bet with this great hand. If I get squeezed from blinds, I don't mind because of playability. Very occasionally against very aggressive villains I'm willing to be all in pre flop. AJ and worse in position, my initial thought is 3bet or fold. Players who fold often to 3bet, or X fold on flop often to c bet, are prime targets for 3bets.
OOP, I will at minimum defend suited A10 upwards, most of the time. I would mix in 3bets with KQ/J, they block a lot of good hands, against people who fold to 3bet/fold to C Bet.
This is just my opinion, I don't play much 6 handed NL. My advice about AQs maybe slightly non-standard.