Vilain calls flop,bet 1bb turn and 2bb river,for me dont make any sense so i raise off bluff.
https://www.cardschat.com/replayer/224tlGoca

If we are going to bluff this - I think I would 3 barrel it here. This current line makes no sense. What are we trying to get to fold on this river? What hand would we do this with? Bet - check - x/raise? Trips are calling you down, flushes are calling you down and certain Aces should be calling you down.

If I were the villan and I had an ace I would've called the flop bet - checked back turn - bet the river for value when checked to and hero called the raise on the end because that line makes very little sense and is repping either a flush or nothing and good players will pay for the answer to that one.

If you think he has nothing you just can call. To me he looks like played 54s,33,44,66. Or he might hit draw want to induce raise.