Lots of variables, Depending on if you play 6max or Full Ring cash games or if you are using it for Tourneys. HOldem manager does have a few videos on the site you can also watch for tips Holdem manager
Also It's just a real good Idea to review your losing hands on the replayer when done with a session or the next day before you start a new session . This is how I like to filter my losing hands . You can also do the same thing to all your winning hands to see if maybe you are losing value on some hands you played . I usually will write down on paper when watching my losing hands, on how much i think I think I could have saved ,if I had played the hand diff then add it all up when done to see where it might have gone wrong.