As I said in PM, I also recommend Parallels over Wine for things like this. However it does cost and requires a Windows license, so some Mac-only users may not consider that a viable option. However I'll caution you that unless you buy a more user-friendly version of Wine such as CrossOver, using vanilla Wine and tweaking apps to work can be a geek exercise and not for the technically faint of heart.
You can try installing a Mac port of Wine, such as WineBottler, then running the FlopZilla.msi installer. Navigate to your Wine Apps folder (typically in your Home folder), drive_c\Program Files\FlopZilla (or whichever path you used) and right-click the Flopzilla.exe program and Open With -> Wine. If you get an error about missing DLLs, then Google for what you need to do to install missing dependencies (typically using WineTricks).