Depends on the suits of the flop, position, players I am playing against and pre-flop action. Checking to a pre-flop aggressor in early position is usually a good play on a rainbow flop to either give a card to catch up, to see if anybody got a piece of it to determine how much value I could get on later streets, and to give the opportunity to
bluff. If there was a flush draw out and I didn't have the A of that suit, I would bet, half pot or more, but I would try to balance this out by betting my flush draws as well in other hands.
I think the key to playing boards like this where you have flopped the nuts (depending on the suits of the board cards) is to find out a way to extract maximum value while having a plan if you get outdrawn on the turn or river with a completed flush, or the board pairing making a potential full house for somebody. KQ and QJ (and sometime KJ) are playable hands so I would be trying to figure out if somebody has these cards in the event that the board pairs with these cards, especially the Q.