I find that when players try to make their preflop raises 'look' massive, is more often when I'll 3-bet them.
Personally I'll raise 2.5x (depending upon table) once blinds reach ~60/120.
The reason for this is two-fold (or three, lol)... one it costs me less to steal the blinds but even more importantly if someone calls (or blinds defend), it also costs me a smaller-sized c-bet to take it down postflop (if I'd raised say 3 or 4x, the pot would be much bigger (esp. if 2 callers) and my c-bet would have to be that much bigger as well).
Also, I feel confident in my post-flop skills and like to play pots.
You may have more players defend vs. a smaller preflop raise (although at higher, or even moderately higher than the micros this is pretty much standard raise size now), if you're confident in postflop play this is ok... AND, you will also likely get action when you're holding a monster (aggress. opponents may be more likely to 3-bet preflop because your raise size isn't huge, you could be stealing, etc.... if your raise is HUGE then their 3-bet size will have to be that much bigger as well & will be less likely to play back at ya... when I'm holding a monster I WANT them to play back at me (of course mixing it up by 4-betting light 'occassionally' depending upon villain in hand).