Well, it differ from player to player.
Everyone has his own style of playing, based on past learning experiences and intuition. My style of play is aggressive, regardless of table position.
I do not like playing loose, per se, but I raise quite hard. This style has benefited me a lot.
Also, I do not try to fold the other guy but try to play the hand intelligently - sometimes making gutsy, risky bluffs also
which has paid me off very well.