I play them, very profitable, espically the micros obviously. People have no idea on any sort of range and most definetly just play "their cards" and don't actually try and think of what you could be holding.
One person I played, I paid of a few early show downs just to see what his range of hands was and what he was raising/limping with. After like 10 hands, I could put him on his exact hand almost everytime.
Don't try bluffing
many, you will get an idea of if you can bluff them. You either have all-ins shovers or overly aggressive players who are so explotiable. Take it slowly early stages, get a feel and you should be fine.
I don't like multi tabling heads up, I prefer to get in the "zone" and just 1 table trying to work out ones tendencies.