You generally should look to get it in, however u dont want to overvalue ur hand in some spots where its most likely or almost never good, for example, ur 200bb deep in a tourney at start, u wouldnt want to get it in against any thinking opponent as u will either be flipping(most likely not even that) against QQ or be dominated, or in like deepstack cashgame, but again lets say UTG opens, u 3bet utg+1, button 4bets and utg original opener goes all in for like 100+bb effective, this is easy fold spot again, and flatting might be better if u are like big stack vs big stack on bubble of a tourney coz u dont want to risk bubbling as a big stack ( if opponent covers u on bubble ), other then that, 50bb or less, should always be looking to get it in vs almost every opponent