Depend on table size and stack sizes. In cash games and early on in tournaments, you can pretty much always open any pair from any position, if there are 6 or less players at the table. With more than 6 players, it is usually best to simply fold the smallest pairs from the first few seats.
And if stacks get into some kind of intermediate territory like 30BB, where you are to shallow to setmine, but to deep to jam, its also fine to sometimes just fold the smallest pairs, even if you only have a few people left to act after you. It will depend also, how deep are the other players, can someone behind jam on you, etc.
Finally each pair is different, and I would always be more likely to play 66 than 22, so taking the smalls pairs out of your range is something gradual, its not an "always or never" thing, black or white. But especially 22-44 are kind of overvalued hands, which people typically tend to play to much, and its rarely going to be that wrong to just dump them.