I'm curious as to which variant of O8 OP is talking about. Is it Pot-Limit, Fixed-Limit, or no-limit? Each game has some distinct differences. For me, I'm not a fan of the No-Limit variant of the game.
Here are some things to consider in playing O8 regardless of the variant.
Hands with a 9 in it are almost useless. Even AA29 in certain spots are extremely vulnerable to being quartered in multi-way pots. Think of it as having a 3 legged chair.
Middle pairs (6-10's) are to be played carefully, if at all. Even if you flop a set, you're usually up against a bigger set, or some re-draw to a flush or straight.
Even if you have a hand like AA23, AA24, you'll want to be suited. If those hands are rainbow, you automatically take away the possibility of making a flush.
Nut low hands (A2xx) in multi-way pots can be vulnerable of being quartered, especially if xx are not other low cards, like 3, 4, or 5.
Case in point, I was playing some 5 card PLO8 earlier, and had A2xxx (xxx didn't contain a 3 or a 4) and there were 3 people in the hand to the river and they were all-in at that point, and I would have won 1/3 of the low and none of the high so I would have lot a big portion of my stack. But, I folded on the flop and only lost 3 bb's instead of 90 bb's.
A lot of Hold'em players overplay AAxx in Omaha too.