Your question really has many different answers depending on a number of different factors, but for simplicity sake let’s go with a straight forward example.
1] When I have roughly
half the amount of chips in a HU compared to an opponent: I personally take a defensive position by folding my weak
hands on any preflop raises and even folding half my blinds with I am in the small blind positions if my cards are extremely poor. When I get cards that I can defend, depending on how my opponent’s acts preflop will determine how I play my cards in that specific hand.
2] When I have the
chip lead in a HU, I will put pressure on the opponent, but I also pay close attention on how they react to my pressure, meaning if I place too many large raises with mediocre hands, will this opponent get so frustrated with my constant aggression that they shove allin which will then cause me to have to fold and lose too large of a Aggressive
bluff raise.
So I try to use my aggression carefully in situations like these.