Almost always open on the button, and almost c-bet often, especially if an Ace hit (because they usually re-raise pre-flop if they have an Ace).
I open to 2.5 bb's. I think 3 bb's is too much.
When an overcard hits the turn, that's a good spot to bet.
If someone folds to your raises a lot, and then re-raises you when you have A/5, just much the hand. Your kicker sucks, and you get plenty of free money from all the blinds he's folding off.
Basically, you keep the pressure on when you're in position. Sometimes they fight back and then you fold.
Eventually he'll call with like K/T or A/4 or something, and your junk will hit two pair when he hits top pair and you stack him. Or you'll have a better kicker or whatever.
Of course, if he keeps fighting back you change gears.
Basically, HU you are playing the player not your cards.
I think Maid Marian watched me play a S&G a couple nights ago. When I got HU, I won 22 out of my last 24
hands. In those two hands he re-raised me, so I just folded. Why gamble against easy money?