first is an easy, easy fold. 6 people limp, so somebody more than likely has something. especially true with V3.
Second one: we don't know a V21 but generally fold against someone raising very early unless they are pretty loose, they will have better than you. Of course this is assuming the people you are playing against a good enough to understand the importance of position. If they don't, there is probably a 50/50 chance you have the better hand here. even so, pretty big risk of running into an ace with a better kicker.
I'd say I fold it about 80-90% if the time.