It would depend on betting patterns and position. If I raised pre and got one call from the blinds, and now this person bets into me post flop, I would be thinking maybe either Kx or a small pocket pair.
Pot
odds should also be considered, a bet of 30 chips from the villain when the pot is 360 is obviously much more enticing to call than a bet of 400 when the pot is 100.
There's a lot more to take into account than just hole cards and what's on the board, but if someone in earlier position is betting on a paired board that I haven't connected with at all, I would be inclined to fold it in the absence of any player reads.