Ok, I'll jump in on this, and let you decide if it's good or bad.
If you are in Position (Assuming you are), and villain 2xraises alot and you 3bet him and he calls often...Now assuming the flop comes J/10/6 (R), now since you're in position already (that's a benefit), because you get to see what he/she does on every street, and this will help you to narrow down the players range of hands that you put him/her on by the way they've been playing thus far...So on this flop, now villain comes out betting (taking into account how aggressive he/she plays, you can choose a path which is safe and sound)...So lets assume you just flat villain now..You flat the raise from villain so you don't blow the pot up in position with just TPTK and also to see how they react on the turn+let them keep their bluffs in and last but not least to keep chips in the off chance that all the scare cards hit that could potentially be in villains hand (K/Q/A/9/8/7), that's alot of hands to worry about yes, but this way is safer than the alternative, which would be (You re-raise their bet on the flop and they shove, and you end up stacking off vs them with only TPTK, don't you agree)? So now on the turn (Lets just say the turn was the Deuce) , once again it's up to villain to make a decision (since your in position), and now they choose to check (Well since they bet out into you on the flop, and checked to you on the turn, than you can safely assume their holdings to be one of these hands, KQ/AK/QJ/98/97/87/Q8//Q9/ and 10x type of hands, and will also add QJ...So what should you do in this case (This would depend on your read on villain), does he/she bet out with draws, and shut down on turns when it doesn't hit? Are they the type that trap with sets+2 pair hands, and bet flop and check turn hoping that you take the bait? Do they play any smaller pairs in this manner, 7s< Do they bet out on gutter draws 1 time and shut down on turn if it doesn't complete?
These are the things you need to worry more so about when playing hands like TPTK vs anyone really because if the straight card happens on the turn, and your just betting away, than is it really villains fault that he hit is card and you didn't notice? Or is it yours?