It all depends....lol. Q8 is pretty much a fold to most(!) raises. The thing is, why are you doing anything. Ask yourself WHY, and if you dont have an answer, fold.
I will give you an example.
Tight player in MP raises 3x, you have ATC (any two cards) that are pretty much trash like Q8. You know this player will raise with Axs, any PP, most BW hands and highish SC, and he will 4 bet you with AK, AA-JJ and call with maybe 50% of his other hands, but you also know he will check when he misses the flop. You can 3 bet here with a plan of raising his checks OTF and folding to his 4 bet. Things like flop texture and other stuff must also be taken into consideration. You raise with a plan and you know why you are doing it, and how you will proceed. You need to be IP vs this guy to do this. From the blinds it is a 3 bet only if you really think you can get him to fold most of his hands, but Q8 from the blinds is pretty much just muck it now. But, it really all depends....... How I used to hate reading that, but it is sooooooo true.........
If you dont know WHY, folding is your friend.
EDIT: Calling with trash is almost never a good idea. Raise or fold.