By calling you give them their equity in the pot for free (which even for 22 is substantial with implied odds
You need to 3bet your big pocket pairs so that they're in your 3betting range, if your opponents really fold 80% of the time to 3bets (and they don't, it's closer to 65%-70% unless you're a nit) then you should be 3betting light (a lot), a raise of 3x/4x their bet will show a proffit with any two cards. The only way you can 3bet light is by still having big pocket pairs in your range.
In other words: If they fold too much to 3bets, that's what you should be exploiting.
Also, playing one pair hands post flop is so much easier and more proffitable when the pot is big relative to the stacks so building a pot pre-flop is very, very good.