First of all, it is a filthy bastard game that will rob your soul of its shine, remove the twinkle from your eye and leave you muttering to yourself at night. I hate this game the way normal poker players hate razz.
But if you must play it, some basic advice:
1) Don't start a hand OOP with less than three to a seven, preferably without a 6 (6s make it hard to make made hands without straights).
2) Do not forget that unlike razz, straights and flushes *do* count against you.
3) Position is incredibly important, you must bluff heavily and catch your opponents bluffing