well I think it is understand we are essentially always "semi-bluffing for value" with AK.
If we were to flat AK to keep dominated hands in, which, really, is probably an overrated idea anyway, I'd rather do it in the BB vs. a BTN opener who is going to have all Ax/Kx not to mention Q-high and worse in his range. This guy in particular is not going to have a lot of those hands to begin with so flatting to keep in the hands we're crushing is of minimal value.
We should be able to play against a range with 40% equity and position profitably.
If we want to fold to a small 4-bet that utterly reeks of strength in this spot, that's also fine. So if we assume he is never flatting with AA/KK we become a pretty healthy favorite over TT-QQ/AQ+.
The problem is -- to play profitably against whatever his continuing range is, we need to pump more money into the pot preflop and deny him odds
to call with set-mining hands and also to extract value from the hands that aren't going to put a cent into the pot after we flop top pair.
Also, if he flats pre with AK we become a pretty huge favorite to win the pot if we 3-bet precisely because we have position and iniative. Whereas if we flat and he cbets AK on a 633 flop we probably fold.