What hurts me the most is making the right read and play, only to have it not hold up on the river. In poker all you can do is get your money in ahead and hope it holds up. In the long run you want weaker hands in the pot verses your strong hands, you will profit more then you lose. Because of the luck factor any one can have a great run as well as bad runs. Timed aggression is a big key to winning consistently on the poker tables. Common sense says the more you play certain players the better you should get verse the same players. Your reads will become clearer and you will noticed yourself making plays without even thinking about it verses some players. Making the right decision at the right times, such as when to reraise and when to just call. When to go for max gain in a hand verses min lose.