It's a pretty good observation. AKos vs TJs vs 22, you let me pick second and you'll lose every single time.
QJ suited plays decently heads up but obviously is significantly worse than AK. You can run into over pairs because you don't have the blockers. Also, in heads up play top pair is generally nutter butters so if you have QJ against AQ KQ or AJ you could potentially be in a devastatingly bad situation in regards to your reverse implied odds.