Impossible to answer unless you are more specific.
Are we talking Holdem ?
Limit, Pot, No Limit ?
Full Table or Short Handed ?
STT, MTT or Ring Game ?
If Tourney, what blind level and what is the wider strategic situation ?
Reads on other players ?
Relative size of chip stacks.
etc., etc., I could go on all day.
In any case, it`s a mistake to get too hung up on preflop play. That`s only a small part of the game. Read this thread for example:
I realise I am not being very helpful. Not trying to be rude. Describe what you want to know more clearly and I`ll try to help.
Or, if you`re very lucky, one of the good players might.