PokerOffice has better live feed during games; in addition to statistics you get the betting history for the ongoing hand (i.e. if someone raises $2 preflop and bets out $4 on the flop it will say "R2.0|B4.0" under this player) as well as odds, everything on the table overlay. Before the 2nd version of PO I used PT for game analysis and PO during play, but there is no need for PT anymore since a replayer (with overlay) has been added in PokerOffice2.
Also, PO2 is very easy to set up..just install and every thing should work out of the box. I recommend switching to the MySQL databse (see the "howto" in the PO forum) to speed up things..