"It depends".
If you are in the big blind and can see the flop at a good rate, then play it whether short stacked or not.
If short stacked and not in the blinds, then muck it.
If big stacked and feeling froggy, see the flop with it if the price is right.
I love playing hands like that, but only if I think I'll get paid off if I hit. If 6 people limp, I'm playing it. If its likely gonna be me and the blinds, I dont waste the chips.
The problem is as far as big hands go, you're not going to make very many. If you hit 2 pair and get one of the 6 limpers to stack it's likely they have a set or better 2 pair. People talk all about odds but you also have to consider that you now have to beat 6 hands. Also remember that if you flop big you likely aren't getting paid unless you're beat. Sure you have the players who will pay you off with top pair when 7 people saw the flop, but generally in multi-way pots you're not going to get all the money in against someone with 1 pair.
I guess I should have explained better. When I play a hand like that against 6 people I'm not looking for top pair, I'm looking for a straight or a flush. Let the other guy hit 2 pair.
One of the best tournament players I ever saw would insist that the only time to play these was shoving when you are very shortstacked.
His reasoning was that you are going to get called by players with high cards, and increasing your chances of having two live cards was important, rather than getting caught in A6 vs. AK situations.