Not even close - just the fact that you have to use 2 cards makes it a lot different.
Spoken like someone who doesn't play a lot of Omaha...
Most winning hands in NLHE use two. And the fact that Omaha forces you to use two just slightly alters how you read the board (QQ > AK on a 222A4 board obviously). This isn't a big change.
Not to mention that the most you can bet in PLO is POT.
95% of bets in NLHE are pot sized.
The big difference in the game is that draws have significantly more
equity in PLO than in NLHE. In NLHE, paying off weak draws is pretty standard, since often your opponent wasn't getting
pot odds to chase them. But with PLO, the turn & river cards have a bigger influence on the value of your hand, and your opponent is likely getting odds to try and hit their stronger draws. Thus, it makes things more of a postflop game.
However, PLO is the most similar game you can find to NLHE without getting into those weird variants like pineapple. While PLO may require you to make a few adjustments from how you play NLHE, you'll have to make bigger adjustments when switching to any other game from NLHE.
So, if I had to say it in one sentence: Once you've learned NLHE, the next easiest game to learn is probably PLO.
I spend most of my time these days playing limit games (stud & LO8 mostly), and the skill set used in those games is a bigger departure from hold'em than PLO is.