I used a program to help me with pot odds
and win odds when I first started playing, but in hindsight I think it slowed my game down. It made me lazy in not learning how to correctly calculate odds, and now I find that I can do it just as quickly in my head.
I do however use Holdem Indicator once in a while to keep track of how players are betting when I'm multi-tabling. It helps to give you an idea but isn't a huge advantage. I'm probably going to shop around for something else to keep better track of my own play rather than my opponents.